LEAP Instrument (Cyntellect, http://www.cyntellect.com)
LEAP is an automated live cell analysis and processing system for in-situ laser-based cell purification and/or transfection. LEAP combines ultra high-speed imaging and multi-parameter visual characterization of cells with simultaneous laser-based cell manipulation.

• Integrates imaging (brightfield and multi-wavelength fluorescence), transfection, and cell purification at high speed, with single cell precision, on both adherent and non-adherent cells in a standard microtiter plate format.
• Uses short intense pulses of visible-wavelength laser light to introduce DNA, RNA, proteins, dyes, chemicals, and even nanoparticles, into a wide variety of mammalian cells at rates up to 1000 cells per second.
• At higher power, the same laser used for optoinjection, can be used to selectively ablate cells from a population based on an optical phenotype (fluorescence, morphology, etc.). This permits any user-selected sub-population of cells to be eliminated, thereby purifying the remaining population for subsequent analysis.
• Integrated software allows cell sub-populations to be selected/gated based on optical phenotypes. 96- or 384-well plates are automatically processed according to these settings.
• Processes adherent or non-adherent samples in situ.